Overexpression of Endometrial Estrogen Receptor-Alpha in The Window of Implantation in Women with Unexplained Infertility

Objective Background: Failure in the endometrial receptivity may account for a significant number of infertility cases including unexplained infertility in women. Reduction in the endometrial estrogen receptor-alpha (ER-α) expression during window of implantation may be a critical event that coincides with expression of specific genes and providing a receptive endometrium. The aim of present study was to assess expression of ER-α in the mid-secretory phase in the endometrium of women with unexplained infertility. MaterialsAndMethods Materials and Methods: This case-control study was carried out on randomly selected fertile (n=10) and unexplained infertile (n=16) women. We evaluated the expression of ER-α and glycodelin-A (GdA) through mRNA level measurement with real-time PCR in the endometrium of infertile patients with unexplained infertility and fertile women. Endometrial biopsies were collected during a single menstrual cycle on postovulatory day LH+7 in each subject. Results Results: Endometrial expression level of ER-α was significantly (p